The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B ce...

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Autors principals: Carotta, Sebastian, Willis, Simon N., Hasbold, Jhagvaral, Inouye, Michael, Pang, Swee Heng Milon, Emslie, Dianne, Light, Amanda, Chopin, Michael, Shi, Wei, Wang, Hongsheng, Morse, Herbert C., Tarlinton, David M., Corcoran, Lynn M., Hodgkin, Philip D., Nutt, Stephen L.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203955/
https://ncbi.nlm.nih.gov/pubmed/25288399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140425
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