The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B ce...

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Auteurs principaux: Carotta, Sebastian, Willis, Simon N., Hasbold, Jhagvaral, Inouye, Michael, Pang, Swee Heng Milon, Emslie, Dianne, Light, Amanda, Chopin, Michael, Shi, Wei, Wang, Hongsheng, Morse, Herbert C., Tarlinton, David M., Corcoran, Lynn M., Hodgkin, Philip D., Nutt, Stephen L.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203955/
https://ncbi.nlm.nih.gov/pubmed/25288399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140425
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