Homologous Recombination Is a Primary Pathway to Repair DNA Double-Strand Breaks Generated during DNA Rereplication

Re-initiation of DNA replication at origins within a given cell cycle would result in DNA rereplication, which can lead to genome instability and tumorigenesis. DNA rereplication can be induced by loss of licensing control at cellular replication origins, or by viral protein-driven multiple rounds o...

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Bibliographic Details
Main Authors: Truong, Lan N., Li, Yongjiang, Sun, Emily, Ang, Katrina, Hwang, Patty Yi-Hwa, Wu, Xiaohua
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200250/
https://ncbi.nlm.nih.gov/pubmed/25160628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.576488
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