A post-translational regulatory switch on UPF1 controls targeted mRNA degradation

Nonsense-mediated mRNA decay (NMD) controls the quality of eukaryotic gene expression and also degrades physiologic mRNAs. How NMD targets are identified is incompletely understood. A central NMD factor is the ATP-dependent RNA helicase upframeshift 1 (UPF1). Neither the distance in space between th...

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Autori principali: Kurosaki, Tatsuaki, Li, Wencheng, Hoque, Mainul, Popp, Maximilian W.-L., Ermolenko, Dmitri N., Tian, Bin, Maquat, Lynne E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197951/
https://ncbi.nlm.nih.gov/pubmed/25184677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.245506.114
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