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Rules that govern UPF1 binding to mRNA 3′ UTRs
Nonsense-mediated mRNA decay (NMD), which degrades transcripts harboring a premature termination codon (PTC), depends on the helicase up-frameshift 1 (UPF1). However, mRNAs that are not NMD targets also bind UPF1. What governs the timing, position, and function of UPF1 binding to mRNAs remains uncle...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3587222/ https://ncbi.nlm.nih.gov/pubmed/23404710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219908110 |
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