Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

In mammalian cells, nonsense-mediated mRNA decay (NMD) generally requires that translation terminates sufficiently upstream of a post-splicing exon junction complex (EJC) during a pioneer round of translation. The subsequent binding of Upf1 to the EJC triggers Upf1 phosphorylation. We provide eviden...

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Huvudupphovsmän: Isken, Olaf, Kim, Yoon Ki, Hosoda, Nao, Mayeur, Greg L., Hershey, John W.B., Maquat, Lynne E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193665/
https://ncbi.nlm.nih.gov/pubmed/18423202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.02.030
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