Role for Upf2p Phosphorylation in Saccharomyces cerevisiae Nonsense-Mediated mRNA Decay

Premature termination (nonsense) codons trigger rapid mRNA decay by the nonsense-mediated mRNA decay (NMD) pathway. Two conserved proteins essential for NMD, UPF1 and UPF2, are phosphorylated in higher eukaryotes. The phosphorylation and dephosphorylation of UPF1 appear to be crucial for NMD, as blo...

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Main Authors: Wang, Weirong, Cajigas, Iván J., Peltz, Stuart W., Wilkinson, Miles F., González, Carlos I.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1447418/
https://ncbi.nlm.nih.gov/pubmed/16611983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.9.3390-3400.2006
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