Role for Upf2p Phosphorylation in Saccharomyces cerevisiae Nonsense-Mediated mRNA Decay

Premature termination (nonsense) codons trigger rapid mRNA decay by the nonsense-mediated mRNA decay (NMD) pathway. Two conserved proteins essential for NMD, UPF1 and UPF2, are phosphorylated in higher eukaryotes. The phosphorylation and dephosphorylation of UPF1 appear to be crucial for NMD, as blo...

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Bibliographic Details
Main Authors: Wang, Weirong, Cajigas, Iván J., Peltz, Stuart W., Wilkinson, Miles F., González, Carlos I.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1447418/
https://ncbi.nlm.nih.gov/pubmed/16611983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.9.3390-3400.2006
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