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Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay
In mammalian cells, nonsense-mediated mRNA decay (NMD) generally requires that translation terminates sufficiently upstream of a post-splicing exon junction complex (EJC) during a pioneer round of translation. The subsequent binding of Upf1 to the EJC triggers Upf1 phosphorylation. We provide eviden...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4193665/ https://ncbi.nlm.nih.gov/pubmed/18423202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.02.030 |
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