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Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State

One outcome of activation of the phosphatidylinositol 3-kinase (PI3K) pathway is increased aerobic glycolysis, but the upstream signaling events that regulate the PI3K pathway, and thus the Warburg effect, are elusive. Increasing evidence suggests that Plk1, a cell cycle regulator, is also involved...

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Hlavní autoři: Li, Zhiguo, Li, Jie, Bi, Pengpeng, Lu, Ying, Burcham, Grant, Elzey, Bennett D., Ratliff, Timothy, Konieczny, Stephen F., Ahmad, Nihal, Kuang, Shihuan, Liu, Xiaoqi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187734/
https://ncbi.nlm.nih.gov/pubmed/25047839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00814-14
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