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Inhibition of Polo-like Kinase 1 (Plk1) Enhances the Antineoplastic Activity of Metformin in Prostate Cancer

The widely used anti-diabetic drug metformin has been shown to exert strong antineoplastic actions in numerous tumor types, including prostate cancer (PCa). In this study, we show that BI2536, a specific Plk1 inhibitor, acted synergistically with metformin in inhibiting PCa cell proliferation. Furth...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Shao, Chen, Ahmad, Nihal, Hodges, Kurt, Kuang, Shihuan, Ratliff, Tim, Liu, Xiaoqi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303657/
https://ncbi.nlm.nih.gov/pubmed/25505174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.596817
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