Inhibition of Polo-like Kinase 1 (Plk1) Enhances the Antineoplastic Activity of Metformin in Prostate Cancer

The widely used anti-diabetic drug metformin has been shown to exert strong antineoplastic actions in numerous tumor types, including prostate cancer (PCa). In this study, we show that BI2536, a specific Plk1 inhibitor, acted synergistically with metformin in inhibiting PCa cell proliferation. Furth...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Shao, Chen, Ahmad, Nihal, Hodges, Kurt, Kuang, Shihuan, Ratliff, Tim, Liu, Xiaoqi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303657/
https://ncbi.nlm.nih.gov/pubmed/25505174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.596817
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker