Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer Formation

Loss of the tumor suppressor Pten (phosphatase and tensin homolog deleted on chromosome 10) is thought to mediate the majority of prostate cancers, but the molecular mechanism remains elusive. In this study, we demonstrate that Pten-depleted cells suffer from mitotic stress and that nuclear function...

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Autors principals: Liu, X. Shawn, Song, Bing, Elzey, Bennett D., Ratliff, Timothy L., Konieczny, Stephen F., Cheng, Liang, Ahmad, Nihal, Liu, Xiaoqi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195584/
https://ncbi.nlm.nih.gov/pubmed/21890624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.269050
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