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Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response

The mitotic kinase Plk1 contributes to the DNA damage response (DDR) by targeting multiple factors downstream of the core responder kinase ATM/ATR. In this study, we show that Plk1 also phosphorylates key factors upstream of ATM/ATR and regulates their DDR-related functions. Plk1 phosphorylated Mre1...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Li, Zhiguo, Li, Jie, Kong, Yifan, Yan, Shan, Ahmad, Nihal, Liu, Xiaoqi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504882/
https://ncbi.nlm.nih.gov/pubmed/28512243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2787
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