Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11

Ataxia telangiectasia mutant (ATM) is an S/T-Q–directed kinase that is critical for the cellular response to double-stranded breaks (DSBs) in DNA. Following DNA damage, ATM is activated and recruited by the MRN protein complex [meiotic recombination 11 (Mre11)/DNA repair protein Rad50/Nijmegen break...

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Detalhes bibliográficos
Main Authors: Chen, Chen, Zhang, Liguo, Huang, Nai-Jia, Huang, Bofu, Kornbluth, Sally
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870678/
https://ncbi.nlm.nih.gov/pubmed/24297933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306328110
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