Metabolic Control of Ca(2+)/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Caspase-2 Suppression by the B55β/Protein Phosphatase 2A (PP2A)

High levels of metabolic activity confer resistance to apoptosis. Caspase-2, an apoptotic initiator, can be suppressed by high levels of nutrient flux through the pentose phosphate pathway. This metabolic control is exerted via inhibitory phosphorylation of the caspase-2 prodomain by activated Ca(2+...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Huang, Bofu, Yang, Chih-Sheng, Wojton, Jeffrey, Huang, Nai-Jia, Chen, Chen, Soderblom, Erik J., Zhang, Liguo, Kornbluth, Sally
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276857/
https://ncbi.nlm.nih.gov/pubmed/25378403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585844
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