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Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes
Mre11/Rad50/Nbs1 complex (MRN) is essential to suppress the generation of double-strand breaks (DSBs) during DNA replication. MRN also plays a role in the response to DSBs created by DNA damage. Hypomorphic mutations in Mre11 (which causes an ataxia-telangiectasia-like disease [ATLD]) and mutations...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC406388/ https://ncbi.nlm.nih.gov/pubmed/15138496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020110 |
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