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Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11
Ataxia telangiectasia mutant (ATM) is an S/T-Q–directed kinase that is critical for the cellular response to double-stranded breaks (DSBs) in DNA. Following DNA damage, ATM is activated and recruited by the MRN protein complex [meiotic recombination 11 (Mre11)/DNA repair protein Rad50/Nijmegen break...
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| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870678/ https://ncbi.nlm.nih.gov/pubmed/24297933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306328110 |
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