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Plk1 phosphorylation of Numb leads to impaired DNA damage response

Although Numb is well-recognized as a cell-fate determinant in stem/progenitor cells, accumulating evidence supports that Numb also has a critical role in adult tissues and cancers, in particular, in the context of regulation of tumor suppressor p53. Herein, we identified Numb as a novel substrate o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncogene
Prif Awduron: Shao, C, Chien, S-J, Farah, E, Li, Z, Ahmad, N, Liu, X
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931337/
https://ncbi.nlm.nih.gov/pubmed/29059161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.379
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