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Plk1 Phosphorylation of Orc2 Promotes DNA Replication under Conditions of Stress
Polo-like kinase 1 (Plk1) plays pivotal roles in mitosis; however, little is known about its function in S phase. In this study, we show that inhibition of Plk1 impairs DNA replication and results in slow S-phase progression in cultured cancer cells. We have identified origin recognition complex 2 (...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232917/ https://ncbi.nlm.nih.gov/pubmed/21947279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06110-11 |
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