Glutathionylation Mediates Angiotensin II–Induced eNOS Uncoupling, Amplifying NADPH Oxidase‐Dependent Endothelial Dysfunction

BACKGROUND: Glutathionylation of endothelial nitric oxide synthase (eNOS) “uncouples” the enzyme, switching its function from nitric oxide (NO) to O(2)(•−) generation. We examined whether this reversible redox modification plays a role in angiotensin II (Ang II)‐induced endothelial dysfunction. METH...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Galougahi, Keyvan Karimi, Liu, Chia‐Chi, Gentile, Carmine, Kok, Cindy, Nunez, Andrea, Garcia, Alvaro, Fry, Natasha A. S., Davies, Michael J., Hawkins, Clare L., Rasmussen, Helge H., Figtree, Gemma A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Publishing Ltd 2014
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187489/
https://ncbi.nlm.nih.gov/pubmed/24755153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000731
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk