TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice

CTLA-4 is a co-receptor that plays a pivotal role in regulating the threshold for T-cell activation. We recently reported that CTLA-4 ligation can over-ride the stop-signal induced by anti-CD3 ligation [Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, et al. Reversal of the TCR sto...

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Bibliographic Details
Main Authors: Downey, Jos, Smith, Andrew, Schneider, Helga, Hogg, Nancy, Rudd, Christopher E.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186962/
https://ncbi.nlm.nih.gov/pubmed/17964663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2007.09.004
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