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CTLA-4 trafficking and surface expression

The T-cell co-receptor cytotoxic T-cell antigen 4 (CTLA-4) has a strong inhibitory role as shown by the lymphoproliferative phenotype of CTLA-4-deficient mice. Despite its potent effects on T-cell function, CTLA-4 is primarily an intracellular antigen whose surface expression is tightly regulated by...

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Autores principales: Valk, Elke, Rudd, Christopher E., Schneider, Helga
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186961/
https://ncbi.nlm.nih.gov/pubmed/18468488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2008.02.011
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