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Diverse Mechanisms Regulate the Surface Expression of Immunotherapeutic Target CTLA-4
T-cell co-receptor cytotoxic T-cell antigen-4 (CTLA-4) is a critical inhibitory regulator of T-cell immunity and antibody blockade of the co-receptor has been shown to be effective in tumor immunotherapy. Paradoxically, the majority of CTLA-4 is located in intracellular compartments from where it is...
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| Опубликовано в: : | Front Immunol |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255484/ https://ncbi.nlm.nih.gov/pubmed/25538704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00619 |
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