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TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis

Foxp3(+) T regulatory cells (Tregs), conventional CD4(+)Foxp3(−) T cells, and CD8(+) T cells represent heterogeneous populations composed of naïve-phenotype (NP, CD44(low)) and memory-phenotype (MP, CD44(high)) subpopulations. NP and MP subsets differ in their activation state, contribution to immun...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Holt, Michael P., Punkosdy, George A., Glass, Deborah D., Shevach, Ethan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296272/
https://ncbi.nlm.nih.gov/pubmed/28053234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601670
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