BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism

Expression of hepcidin, the hepatic hormone controlling iron homeostasis, is regulated by bone morphogenetic protein (BMP) signaling. We sought to identify which BMP type II receptor expressed in hepatocytes, ActR2a or BMPR2, is responsible for regulating hepcidin gene expression. We studied Bmpr2 h...

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Hlavní autoři: Mayeur, Claire, Leyton, Patricio A., Kolodziej, Starsha A., Yu, Binglan, Bloch, Kenneth D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186540/
https://ncbi.nlm.nih.gov/pubmed/25075125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-572644
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