CYR61/CCN1 overexpression in the myeloma microenvironment is associated with superior survival and reduced bone disease

Secreted protein CCN1, encoded by CYR61, is involved in wound healing, angiogenesis, and osteoblast differentiation. We identified CCN1 as a microenvironmental factor produced by mesenchymal cells and overexpressed in bones of a subset of patients with monoclonal gammopathy of undetermined significa...

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Bibliographische Detailangaben
Hauptverfasser: Johnson, Sarah K., Stewart, James P., Bam, Rakesh, Qu, Pingping, Barlogie, Bart, van Rhee, Frits, Shaughnessy, John D., Epstein, Joshua, Yaccoby, Shmuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2014
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186535/
https://ncbi.nlm.nih.gov/pubmed/25061178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555813
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