NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity

Multiple myeloma (MM) cells typically grow in focal lesions, stimulating osteoclasts that destroy bone and support MM. Osteoclasts and MM cells are hypermetabolic. The coenzyme nicotinamide adenine dinucleotide (NAD(+)) is not only essential for cellular metabolism; it also affects activity of NAD-d...

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Detalhes bibliográficos
Publicado no:Exp Hematol
Main Authors: Venkateshaiah, Sathisha Upparahalli, Khan, Sharmin, Ling, Wen, Bam, Rakesh, Li, Xin, van Rhee, Frits, Usmani, Saad, Barlogie, Bart, Epstein, Joshua, Yaccoby, Shmuel
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648259/
https://ncbi.nlm.nih.gov/pubmed/23435312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2013.02.008
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