NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity

Multiple myeloma (MM) cells typically grow in focal lesions, stimulating osteoclasts that destroy bone and support MM. Osteoclasts and MM cells are hypermetabolic. The coenzyme nicotinamide adenine dinucleotide (NAD(+)) is not only essential for cellular metabolism; it also affects activity of NAD-d...

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Bibliografische gegevens
Gepubliceerd in:Exp Hematol
Hoofdauteurs: Venkateshaiah, Sathisha Upparahalli, Khan, Sharmin, Ling, Wen, Bam, Rakesh, Li, Xin, van Rhee, Frits, Usmani, Saad, Barlogie, Bart, Epstein, Joshua, Yaccoby, Shmuel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648259/
https://ncbi.nlm.nih.gov/pubmed/23435312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2013.02.008
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