NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity

Multiple myeloma (MM) cells typically grow in focal lesions, stimulating osteoclasts that destroy bone and support MM. Osteoclasts and MM cells are hypermetabolic. The coenzyme nicotinamide adenine dinucleotide (NAD(+)) is not only essential for cellular metabolism; it also affects activity of NAD-d...

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Dettagli Bibliografici
Pubblicato in:Exp Hematol
Autori principali: Venkateshaiah, Sathisha Upparahalli, Khan, Sharmin, Ling, Wen, Bam, Rakesh, Li, Xin, van Rhee, Frits, Usmani, Saad, Barlogie, Bart, Epstein, Joshua, Yaccoby, Shmuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648259/
https://ncbi.nlm.nih.gov/pubmed/23435312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2013.02.008
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