The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth

Myeloma bone disease is caused by uncoupling of osteoclastic bone resorption and osteoblastic bone formation. Bidirectional signaling between the cell-surface ligand ephrinB2 and its receptor, EphB4, is involved in the coupling of osteoblastogenesis and osteoclastogenesis and in angiogenesis. Ephrin...

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Bibliographic Details
Main Authors: Pennisi, Angela, Ling, Wen, Li, Xin, Khan, Sharmin, Shaughnessy, John D., Barlogie, Bart, Yaccoby, Shmuel
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738568/
https://ncbi.nlm.nih.gov/pubmed/19597185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-201954
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