Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes

Uridine 5′-diphosphate-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that catalyze glucuronidation of various endogenous and exogenous substrates. Among 19 functional human UGTs, UGT1A family enzymes largely contribute to the metabolism of clinically used drugs. While the UG...

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Main Authors: Kutsuno, Yuki, Sumida, Kyohei, Itoh, Tomoo, Tukey, Robert H, Fujiwara, Ryoichi
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2013
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184567/
https://ncbi.nlm.nih.gov/pubmed/25505556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.2
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