Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes

Uridine 5′-diphosphate-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that catalyze glucuronidation of various endogenous and exogenous substrates. Among 19 functional human UGTs, UGT1A family enzymes largely contribute to the metabolism of clinically used drugs. While the UG...

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Autors principals: Kutsuno, Yuki, Sumida, Kyohei, Itoh, Tomoo, Tukey, Robert H, Fujiwara, Ryoichi
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2013
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184567/
https://ncbi.nlm.nih.gov/pubmed/25505556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.2
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