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Tyrosine-based Signal Mediates LRP6 Receptor Endocytosis and Desensitization of Wnt/β-Catenin Pathway Signaling

Wnt/β-catenin signaling orchestrates a number of critical events including cell growth, differentiation, and cell survival during development. Misregulation of this pathway leads to various human diseases, specifically cancers. Endocytosis and phosphorylation of the LDL receptor-related protein 6 (L...

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Bibliografiske detaljer
Main Authors: Liu, Chia-Chen, Kanekiyo, Takahisa, Roth, Barbara, Bu, Guojun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183796/
https://ncbi.nlm.nih.gov/pubmed/25143377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533927
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