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Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling
Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) function as transmembrane receptors to transduce Wnt signals. A key mechanism for signalling is Wnt-induced serine/threonine phosphorylation at conserved PPPSPxS motifs in the LRP6 cytoplasmic domain, which promotes pathway activatio...
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| Publié dans: | EMBO Rep |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BlackWell Publishing Ltd
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4264928/ https://ncbi.nlm.nih.gov/pubmed/25391905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439644 |
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