Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling

Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) function as transmembrane receptors to transduce Wnt signals. A key mechanism for signalling is Wnt-induced serine/threonine phosphorylation at conserved PPPSPxS motifs in the LRP6 cytoplasmic domain, which promotes pathway activatio...

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Enregistré dans:
Détails bibliographiques
Publié dans:EMBO Rep
Auteurs principaux: Chen, Qing, Su, Yi, Wesslowski, Janine, Hagemann, Anja I, Ramialison, Mirana, Wittbrodt, Joachim, Scholpp, Steffen, Davidson, Gary
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2014
Sujets:
Scientific Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264928/
https://ncbi.nlm.nih.gov/pubmed/25391905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439644
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