In vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos

After activation by Wnt/β-Catenin ligands, a multi-protein complex assembles at the clustering membrane-bound receptors and intracellular signal transducers into the so-called Lrp6-signalosome. However, the mechanism of signalosome formation and dissolution is yet not clear. Our imaging studies of l...

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Main Authors: Hagemann, Anja I. H., Kurz, Jennifer, Kauffeld, Silke, Chen, Qing, Reeves, Patrick M., Weber, Sabrina, Schindler, Simone, Davidson, Gary, Kirchhausen, Tomas, Scholpp, Steffen
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163645/
https://ncbi.nlm.nih.gov/pubmed/25074807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.148767
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