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Tyrosine-based Signal Mediates LRP6 Receptor Endocytosis and Desensitization of Wnt/β-Catenin Pathway Signaling

Wnt/β-catenin signaling orchestrates a number of critical events including cell growth, differentiation, and cell survival during development. Misregulation of this pathway leads to various human diseases, specifically cancers. Endocytosis and phosphorylation of the LDL receptor-related protein 6 (L...

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Detalhes bibliográficos
Main Authors: Liu, Chia-Chen, Kanekiyo, Takahisa, Roth, Barbara, Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183796/
https://ncbi.nlm.nih.gov/pubmed/25143377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533927
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