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Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains
Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin light chains and light chain fragments composed of variable domains, which aggregate into amyloid fibers. These fibers accumulate and damage organs. Some light chains induce formation of amyloid fibers, where...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183792/ https://ncbi.nlm.nih.gov/pubmed/25138218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585638 |
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