Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain

Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can undergo irreversible aggregation to the...

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Publicado en:eLife
Autores principales: Brumshtein, Boris, Esswein, Shannon R, Salwinski, Lukasz, Phillips, Martin L, Ly, Alan T, Cascio, Duilio, Sawaya, Michael R, Eisenberg, David S
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758944/
https://ncbi.nlm.nih.gov/pubmed/26576950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10935
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