Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains

Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin light chains and light chain fragments composed of variable domains, which aggregate into amyloid fibers. These fibers accumulate and damage organs. Some light chains induce formation of amyloid fibers, where...

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Detalhes bibliográficos
Main Authors: Brumshtein, Boris, Esswein, Shannon R., Landau, Meytal, Ryan, Christopher M., Whitelegge, Julian P., Phillips, Martin L., Cascio, Duilio, Sawaya, Michael R., Eisenberg, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183792/
https://ncbi.nlm.nih.gov/pubmed/25138218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585638
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