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Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains

Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin light chains and light chain fragments composed of variable domains, which aggregate into amyloid fibers. These fibers accumulate and damage organs. Some light chains induce formation of amyloid fibers, where...

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書誌詳細
主要な著者: Brumshtein, Boris, Esswein, Shannon R., Landau, Meytal, Ryan, Christopher M., Whitelegge, Julian P., Phillips, Martin L., Cascio, Duilio, Sawaya, Michael R., Eisenberg, David S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183792/
https://ncbi.nlm.nih.gov/pubmed/25138218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585638
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