Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains

Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin light chains and light chain fragments composed of variable domains, which aggregate into amyloid fibers. These fibers accumulate and damage organs. Some light chains induce formation of amyloid fibers, where...

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Bibliografski detalji
Glavni autori: Brumshtein, Boris, Esswein, Shannon R., Landau, Meytal, Ryan, Christopher M., Whitelegge, Julian P., Phillips, Martin L., Cascio, Duilio, Sawaya, Michael R., Eisenberg, David S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Molecular Bases of Disease
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183792/
https://ncbi.nlm.nih.gov/pubmed/25138218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585638
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