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Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis
Systemic light-chain amyloidosis (AL) is a human disease caused by overexpression of monoclonal immunoglobulin light chains that form pathogenic amyloid fibrils. These amyloid fibrils deposit in tissues and cause organ failure. Proteins form amyloid fibrils when they partly or fully unfold and expos...
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| Yayımlandı: | J Biol Chem |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314132/ https://ncbi.nlm.nih.gov/pubmed/30355736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004142 |
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