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Molecular basis for amyloid-β polymorphism

Amyloid-beta (Aβ) aggregates are the main constituent of senile plaques, the histological hallmark of Alzheimer’s disease. Aβ molecules form β-sheet containing structures that assemble into a variety of polymorphic oligomers, protofibers, and fibers that exhibit a range of lifetimes and cellular tox...

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Autors principals: Colletier, Jacques-Philippe, Laganowsky, Arthur, Landau, Meytal, Zhao, Minglei, Soriaga, Angela B., Goldschmidt, Lukasz, Flot, David, Cascio, Duilio, Sawaya, Michael R., Eisenberg, David
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193189/
https://ncbi.nlm.nih.gov/pubmed/21949245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112600108
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