Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains

Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin light chains and light chain fragments composed of variable domains, which aggregate into amyloid fibers. These fibers accumulate and damage organs. Some light chains induce formation of amyloid fibers, where...

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Détails bibliographiques
Auteurs principaux: Brumshtein, Boris, Esswein, Shannon R., Landau, Meytal, Ryan, Christopher M., Whitelegge, Julian P., Phillips, Martin L., Cascio, Duilio, Sawaya, Michael R., Eisenberg, David S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183792/
https://ncbi.nlm.nih.gov/pubmed/25138218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585638
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