Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains

Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin light chains and light chain fragments composed of variable domains, which aggregate into amyloid fibers. These fibers accumulate and damage organs. Some light chains induce formation of amyloid fibers, where...

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Autores principales: Brumshtein, Boris, Esswein, Shannon R., Landau, Meytal, Ryan, Christopher M., Whitelegge, Julian P., Phillips, Martin L., Cascio, Duilio, Sawaya, Michael R., Eisenberg, David S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183792/
https://ncbi.nlm.nih.gov/pubmed/25138218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585638
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