Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Our experiments show that Polq-null murine cells are...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Yousefzadeh, Matthew J., Wyatt, David W., Takata, Kei-ichi, Mu, Yunxiang, Hensley, Sean C., Tomida, Junya, Bylund, Göran O., Doublié, Sylvie, Johansson, Erik, Ramsden, Dale A., McBride, Kevin M., Wood, Richard D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183433/
https://ncbi.nlm.nih.gov/pubmed/25275444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004654
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars