Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Our experiments show that Polq-null murine cells are...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yousefzadeh, Matthew J., Wyatt, David W., Takata, Kei-ichi, Mu, Yunxiang, Hensley, Sean C., Tomida, Junya, Bylund, Göran O., Doublié, Sylvie, Johansson, Erik, Ramsden, Dale A., McBride, Kevin M., Wood, Richard D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183433/
https://ncbi.nlm.nih.gov/pubmed/25275444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004654
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