Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Our experiments show that Polq-null murine cells are...

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Detalhes bibliográficos
Main Authors: Yousefzadeh, Matthew J., Wyatt, David W., Takata, Kei-ichi, Mu, Yunxiang, Hensley, Sean C., Tomida, Junya, Bylund, Göran O., Doublié, Sylvie, Johansson, Erik, Ramsden, Dale A., McBride, Kevin M., Wood, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183433/
https://ncbi.nlm.nih.gov/pubmed/25275444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004654
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