Homeostatic IL-23 receptor signaling limits Th17 response through IL-22–mediated containment of commensal microbiota

Mammalian hosts are colonized with commensal microbes in various mucosal and epithelial tissues, including the intestinal tract. In mice, the presence of segmented filamentous bacteria (SFB) promotes Th17 differentiation and the development of autoimmune disease. Here, we demonstrate that the IL-23...

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Hauptverfasser: Shih, Vincent Feng-Sheng, Cox, Jennifer, Kljavin, Noelyn M., Dengler, Hart S., Reichelt, Mike, Kumar, Pawan, Rangell, Linda, Kolls, Jay K., Diehl, Lauri, Ouyang, Wenjun, Ghilardi, Nico
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183330/
https://ncbi.nlm.nih.gov/pubmed/25201978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323852111
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