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IL-27 promotes T cell–dependent colitis through multiple mechanisms

Interleukin-27 (IL-27) is a cytokine known to have both proinflammatory and immunoregulatory functions. The latter appear to dominate in vivo, where IL-27 suppresses TH17 responses and promotes the differentiation of Tr1 cells expressing interferon-γ and IL-10 and lacking forkhead box P3 (Foxp3). Ac...

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Podrobná bibliografie
Hlavní autoři: Cox, Jennifer H., Kljavin, Noelyn M., Ramamoorthi, Nandhini, Diehl, Lauri, Batten, Marcel, Ghilardi, Nico
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023127/
https://ncbi.nlm.nih.gov/pubmed/21173106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100410
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