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IL-27 regulates IL-12 responsiveness of naïve CD4(+) T cells through Stat1-dependent and -independent mechanisms

IL-27, a novel heterodimeric cytokine produced by antigen-presenting cells, signals through the T cell cytokine receptor (TCCR)(/WSX-1) expressed on naïve CD4(+) T cells and natural killer cells. TCCR(/WSX-1) deficiency results in delayed T helper type 1 (T(H)1) development through an unresolved mec...

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Detalhes bibliográficos
Main Authors: Lucas, Sophie, Ghilardi, Nico, Li, Ji, de Sauvage, Frédéric J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC299900/
https://ncbi.nlm.nih.gov/pubmed/14657353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2536517100
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