Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages

Tuberculosis, caused by the intracellular bacterium Mycobacterium tuberculosis, currently causes ∼1.4 million deaths per year, and it therefore remains a leading global health problem. The immune response during tuberculosis remains incompletely understood, particularly regarding immune factors that...

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Detalhes bibliográficos
Main Authors: McNab, Finlay W., Ewbank, John, Howes, Ashleigh, Moreira-Teixeira, Lucia, Martirosyan, Anna, Ghilardi, Nico, Saraiva, Margarida, O’Garra, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2014
Assuntos:
Infectious Disease and Host Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170673/
https://ncbi.nlm.nih.gov/pubmed/25187652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401088
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